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.The structure of ankylosing spondylitis. The structure of ankylosing spondylitis, a frequent but not clinically well defined disease of unknown aetiology, is investigated using new light-microscopic immunocytochemical techniques. Spinal fixative sections of nine patients (six males and three females) who were suffering from ankylosing spondylitis, were examined for the presence of proteoglycans. Our previous investigations of cartilage from other sites have shown that trypsin and collagenase digestions give rise to a large proportion of acidic polysaccharides containing amino sugar, uronic acid and hydroxylated fatty acid residues, detectable by periodic acid-Schiff’s reagent. In the present study spinal sections from three patients who had ankylosing spondylitis, but no osteoarthritis of the spine, were examined for the presence of these aldose sugar residues. It was shown that about 2/3 of the proteoglycans from the spinal ligaments of these patients have a typical structure of ankylosing spondylitis. An analysis of the proteoglycans from the lumbar posterior sacroiliac ligament of ankylosing spondylitis patients show the presence of such aldose sugar residues (3-0-alpha-D-galactose, 3-0-alpha-D-xylose, 3-0-alpha-L-arabinose, 2-0-alpha-L-arabinose). The results are discussed in relation to the pathogenesis of ankylosing spondylitis. INTRODUCTION The New England Revolution’s midfield possession-building needs are seemingly impossible to satisfy. Superstar Wayne Rooney, the club’s only player with no passing instincts, is incapable of holding the ball under pressure and late-game pressure. For years, the Revs have used the 4-3-3 system to recycle the ball, but the team has never been able to push it forward using speed and ingenuity. Against second-tier teams, the Revolution has been able to muddle their way to victory using the wealth of chances provided by possession-based soccer. But when it matters, when they need to break the opponent’s backline, they have been consistently unable to do so. In three playoff games, they failed to capitalize on a combination of bad luck
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