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A new drug being tested in patients suffering from PD at the University of Miami Miller School of Medicine is being developed to help calm the part of the brain that is affected by the disease. The drug is designed to act on a specific receptor on dopamine producing cells in the brain, called the 5HT2A receptor. The receptor helps regulate sleep and wakefulness in normal people but is highly active in PD patients causing an increase in the amount of dopamine in the brain.
“The 5HT2A receptor is one of the few potential targets for the development of drugs to treat PD,” says Carolyn Oltmanns, Ph.D., an associate professor of pharmacology and toxicology at the Miller School and senior author of the study. “The drug developed by our team, called OND-3113, is already in clinical trials and is under review by the Food and Drug Administration. Our data show that OND-3113 is highly active in PD patients and has the potential to lower dopamine levels and improve motor functions in patients with the disease.”
The 5HT2A receptor is part of a family of receptors that are activated by serotonin, a neurotransmitter that interacts with other neurotransmitters such as dopamine. The 5HT2A receptor is found in the brain’s dorsal raphe, the nucleus accumbens and the hippocampus.
The Miller School team began the development of OND-3113 because a drug
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