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Intracerebral administration of progesterone to rats produces a number of physiological changes in the female, including behavioral and hormonal responses, a variety of actions in the reproductive tract and brain, changes in pituitary function, and changes in the body weight of the female. These effects, of central nervous system origin, are thought to be mediated by receptors for the hormone which are found in the brain and, in part, in the pituitary gland and ovaries. Recent studies indicate that receptors for progesterone are confined to a particular compartment within the female brain, namely the hypothalamus. In this study, some of the physiological responses to progesterone were examined following intracerebral administration and were compared with responses produced following systemic administration of the hormone. In the ovariectomized female, systemic administration of progesterone produced a reduction in body weight. In animals implanted with an intracerebral infusion device, progesterone administration produced similar effects on body weight. In contrast, using a supraoptic decussation nucleus implant, rats treated with progesterone intracerebrally displayed a marked increase in body weight. This increase in body weight was accompanied by a rise in plasma luteinizing hormone and ovarian weight. This effect was potentiated when progesterone was combined with testosterone. These data demonstrate that physiological responses to progesterone, which occur by way of receptors in the hypothalamic compartment, may be different in animals given the hormone centrally and in those treated systemically. They also indicate that progesterone’s anabolic actions in the female rat are of central nervous system origin and not due to circulating endogenous steroid hormones.Director Susana Polo watched helplessly as one of her friends attempted to jump into the deep water of the Rio Grande.
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